The Central American side face a tough task to qualify from Group H after losing their opening match against Chile.
But coach Reinaldo Rueda has taken comfort from Switzerland's shock win against the Spanish, which showed that the unexpected can still happen.
"All matches are very different, we are not like the Swiss at all," he admitted. "But the vital factors in that game - determination, conviction, good order and the Swiss will to fight on - we should take into account to counteract Spain's enormous ability on the pitch.
"What we want to do is improve on our performance against Chile and counteract Spain's strengths."
Honduras play Spain in Johannesburg's Ellis Park, a venue accustomed to surprises after South Africa won the 1995 rugby World Cup on its hallowed turf.
Rueda is aware, however, that an even bigger upset would need to occur if his men were to triumph on Monday, but has vowed to approach the game in the correct way nonetheless.
"We know we have to be smart and intelligent and it will depend on our ability to keep the ball."