The former SuperSport United manager has served as South Africa's assistant coach for the past four years but was officially unveiled as the top man on Thursday.
"I have arrived here not to turn things upside down," Mosimane said. "But I will make changes if necessary, even if they are unpopular."
SAFA chief executive Leslie Sedibe revealed they are expecting Mosimane to qualify for the next two African Nations Cups as well as the 2014 World Cup in Brazil.
"Pitso understands fully the performance goals he has to meet," said Sedibe.
"We are impressed and confident that he can achieve them."